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KMID : 1059520080520020118
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Journal of the Korean Chemical Society
2008 Volume.52 No. 2 p.118 ~ p.123
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The Study of Doxorubicin and its Interaction with Adenine by UV-Resonance Raman Spectroscopy
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Lee Chul-Jae
Jung Maeng-Joon
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Abstract
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The interaction of the antitumour agent, doxorubicin, with adenine is investigated in an aqueous solution at a concentration of 10-3~10-4 with volume ratios of 1:2. A UV-resonance Raman spectroscopy and surface enhanced Raman spectroscopy are used to determine the binding sites of doxorubicin to adenine and the structural variations of doxorubicin-adenine complexes in an aqueous solution. We identified that the possibilities of doxorubicin interacted with the N7 positions of adenine.
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KEYWORD
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Doxorubicin, Adenine, Guanine, UV-Resonance Raman Spectroscopy, Surface Enhanced Raman Spectroscopy
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